Lung Cancer

Verified discoveries, trials, and approvals for this cancer type. Every story separates evidence strength, regulatory status, and guideline position.

Latest Discoveries

FDA converts tarlatamab’s accelerated approval to full approval for small cell lung cancer, on a real survival benefit

Evidence stage: High-Certainty EvidenceRegulatory status: FDA Approved
Cancer type
Lung Cancer
Published
August 13, 2026

In the randomized, open-label, phase 3 DeLLphi-304 trial, tarlatamab significantly extended overall survival compared with chemotherapy in patients with extensive-stage small cell lung cancer that had progressed after platinum-based chemotherapy…

Primary source cited

Last reviewed

FDA approves durvalumab as consolidation therapy for limited-stage small cell lung cancer

Evidence stage: Later-Stage HumanRegulatory status: FDA Approved
Cancer type
Lung Cancer
Published
August 13, 2026

In the randomized, placebo-controlled ADRIATIC trial, durvalumab given as consolidation therapy after concurrent chemoradiotherapy meaningfully extended both overall survival and progression-free survival compared with placebo in limited-stage small cell lung…

Primary source cited

Last reviewed

Major Advances

FDA converts tarlatamab’s accelerated approval to full approval for small cell lung cancer, on a real survival benefit

Evidence stage: High-Certainty EvidenceRegulatory status: FDA Approved
Cancer type
Lung Cancer
Published
August 13, 2026

In the randomized, open-label, phase 3 DeLLphi-304 trial, tarlatamab significantly extended overall survival compared with chemotherapy in patients with extensive-stage small cell lung cancer that had progressed after platinum-based chemotherapy…

Primary source cited

Last reviewed

FDA approves durvalumab as consolidation therapy for limited-stage small cell lung cancer

Evidence stage: Later-Stage HumanRegulatory status: FDA Approved
Cancer type
Lung Cancer
Published
August 13, 2026

In the randomized, placebo-controlled ADRIATIC trial, durvalumab given as consolidation therapy after concurrent chemoradiotherapy meaningfully extended both overall survival and progression-free survival compared with placebo in limited-stage small cell lung…

Primary source cited

Last reviewed

Clinical Trials

Important: Eligibility and enrollment are not guaranteed, and listing here is not a treatment recommendation. Talk to your care team.

BNT116 lung-cancer vaccine remains under study in first-in-human trial

Regulatory status: InvestigationalEvidence stage: Early Human
Cancer type
Lung Cancer
Trial identifier
NCT05142189
View trial details
Study design
Non-randomized trial
Population
NSCLC patients (exact eligibility/staging not specified by the frozen source).
Last reviewed
2026-08-11

Regulatory status by jurisdiction

Unspecified jurisdiction

Status
Investigational
Last verified
2026-08-11

This record has no structured cancer-type scope on file yet — editorial review recommended before treating it as applicable to a specific cancer type.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

FDA Approvals

Regulatory approval is separate from evidence certainty and from guideline position. Approval applies only to the exact indication stated in each jurisdiction record.

FDA converts tarlatamab’s accelerated approval to full approval for small cell lung cancer, on a real survival benefit

Regulatory status: FDA ApprovedEvidence stage: High-Certainty Evidence
Cancer type
Lung Cancer
Population
Adults with extensive-stage small cell lung cancer (ES-SCLC) with disease progression on or after platinum-based chemotherapy (with or without an anti-PD-(L)1 agent), randomized to tarlatamab or investigator's choice of chemotherapy, in the phase 3 DeLLphi-304 trial.
View approval details
Last reviewed
2026-08-13

Regulatory status by jurisdiction

United States (FDA)

Status
FDA-approved for the exact stated cancer/use
Indication
Adults with extensive-stage small cell lung cancer with disease progression on or after platinum-based chemotherapy.
Biomarker requirement
DLL3-expressing small cell lung cancer (target of the bispecific antibody; not a patient-selection biomarker test)
Decision date
2025-11-19

Guideline positions

Guideline

Position
Not addressed
Last verified
2026-08-13

Primary evidence supporting this story

Applies to the exact indication stated.

FDA approves durvalumab as consolidation therapy for limited-stage small cell lung cancer

Regulatory status: FDA ApprovedEvidence stage: Later-Stage Human
Cancer type
Lung Cancer
Population
Adults with limited-stage small cell lung cancer (LS-SCLC) whose disease has not progressed following concurrent platinum-based chemotherapy and radiation therapy — a consolidation-therapy approval, not a first-line or newly-diagnosed LS-SCLC treatment broadly, and specifically the durvalumab-monotherapy regimen, not the durvalumab-plus-tremelimumab arm also tested in the same trial.
View approval details
Last reviewed
2026-08-13

Regulatory status by jurisdiction

United States (FDA)

Status
FDA-approved for the exact stated cancer/use
Indication
Adults with LS-SCLC whose disease has not progressed following concurrent platinum-based chemotherapy and radiation therapy, as consolidation therapy with durvalumab monotherapy.
Decision date
2024-12-04

Guideline positions

Guideline

Position
Not addressed
Last verified
2026-08-13

Primary evidence supporting this story

Applies to the exact indication stated.

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Related resources

Trusted resources: official cancer information

CancerDiscoveries summarizes verified records in its database. Absence of a listing here does not establish that a treatment lacks regulatory authorization or access.